West Ham were knocked out of the Europa League as Jeremie Frimpong's late leveller denied them the consolation of becoming the first team to beat new German champions Bayer Leverkusen this season.
Real Madrid beat holders Manchester City on penalties to reach the Champions League semi-finals and end Pep Guardiola’s quest for back-to-back trebles.
Rafael Nadal enjoyed a winning start at the Barcelona Open as he returned from another long-term injury in what could be his final year before retirement.
Kylian Mbappe struck twice as Paris Saint-Germain battled back to beat 10-man Barcelona 4-1 and book a place in the Champions League semi-finals with a 6-4 aggregate triumph on Tuesday.
Borussia Dortmund fought back to beat Atletico Madrid 4-2 in their quarter-final second leg on Tuesday, securing a 5-4 aggregate victory and a first Champions League semi-final since 2013.
Arsenal's Premier League title hopes suffered a massive blow as Aston Villa struck twice in the closing stages to boost their top four bid with a dramatic 2-0 win at the Emirates Stadium on Sunday.
Real Madrid warmed up for a pivotal week in their season with a hard-fought win over Mallorca in La Liga thanks to Aurelien Tchouameni's long-range goal.
Erik ten Hag says it is "up to the fans" whether they remain patient after Manchester United's winless Premier League run extended to four games with their draw at Bournemouth.