A quarter of a century after their memorable previous EURO meeting, when the magic of Paul Gascoigne inspired England to victory, the 'Auld Enemy' meet again.
The Three Lions start as strong favourites after seeing off Croatia in their opener, but the world's oldest international fixture often brings the best out of Scotland, who had their chances against the Czech Republic in Euro 2020 on Monday and now have "a bit of a free hit" according to midfielder John McGinn.
Possible line-ups
England: Pickford; James, Stones, Mings, Shaw; Phillips, Rice, Mount; Foden, Kane, Sterling
Scotland: Marshall; Hendry, Hanley, Tierney; Forrest, McTominay, McGinn, McGregor, Robertson; Armstrong; Adams
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What the coaches say
Gareth Southgate, England manager:
"It's hugely special for everybody involved, and especially the supporters of both teams. So it does add a different dynamic to the qualifying group we're in, there's no question about that. But the good thing is, from our perspective, we had to go to Hampden in qualifying for the World Cup and had the game at Wembley [drawing 2-2 away and winning 3-0 at home]."
McGinn reaction on Scotland defeat
Steve Clarke, Scotland manager: "It's very historic. It goes back a long way; it means a lot. And people say it doesn't mean a lot to the English, but having worked in England I know it means a lot to the English; they don't want to lose to Scotland. And it's the same the other way around. You know how passionate we are, and how much we enjoy beating the English. It hasn't happened too much recently."
England vs Scotland head-to-head
England edge Scotland in the head-to-head stakes.
In 114 meetings, the Three Lions have 48 wins, the Scots have 41 and 25 have ended in a draw.
In recent years however, England have enjoyed near total dominance of games between the two sides, which have become less frequent.
Since 1990, the Three Lions have won five, drawn one and lost one against the Scots.
Scotland's victory came at Wembley when they won 1-0 in a Euro 2000 qualifying play-off, but it wasn't enough to prevent England going through 2-1 on aggregate.
Most of Scotland's success in this fixture came before World War 2 when they won 29 of 63 games compared to just 19 England wins.
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England vs Scotland head-to-head (international tournaments)
England and Scotland have actually met just once at an international tournament.
That game was, of course, England's 2-0 win at Euro 96.
However, the sides have met plenty of times in qualifying for international competitions.
Form guide (all competitions, most recent first)
England: WWWWWW
Scotland: LWDWDD
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