Rafael Nadal's hopes of an 11th Italian Open title are over after defeat to world number nine Hubert Hurkacz.
In what is likely to be the Spaniard's final appearance in Rome, Nadal, 37, was comfortably beaten 6-1 6-3 by the big-serving Pole in just 93 minutes.
Nadal, a 10-time winner in the Italian capital, has indicated that 2024 is likely to be his final season before retirement.
The 14-time French Open champion says he is yet to decide whether to play at Roland Garros this year. The tournament starts on 26 May.
"The decision, as you can imagine, is not clear in my mind today," Nadal said.
"But if I have to say what's my feeling and if my mind is closer one way or the other way, I'm going to say 'be in Roland Garros and try my best'.
"Physically, I have some issues, but not probably yet enough to say not playing in the most important event of my tennis career."
Elsewhere, Great Britain's Cameron Norrie will face Stefanos Tsitsipas after beating Spain's Jaume Munar 6-3 1-6 6-3.
The 28-year-old survived a scare when his form collapsed in the second set, winning just one game.
But Norrie regained his composure in the third set, progressing to the next round despite being well below his best.
British number two Jack Draper was unable to join Norrie in the next round following a 7-5 6-4 defeat by defending champion Daniil Medvedev, who will face qualifier Hamad Medjedovic in the last 32.
Polish world number one Iga Swiatek booked her place in the women's last 16 with a 6-3 6-4 win over Yulia Putintseva.
Swiatek came from 4-1 down in the second set to extend her winning streak to eight matches, and plays Angelique Kerber next after her straight-set win over Aliaksandra Sasnovich.
Naomi Osaka has still not dropped a set in the tournament so far after beating Daria Kasatkina 6-3 6-3.
The Japanese former world number three plays Qinwen Zheng in the last 16.
Coco Gauff survived a scare to book her place in the next round, where she will face Spain's Paula Badosa.
American Gauff, 20, beat Romania's Jaqueline Cristian 6-1 0-6 6-3 in just over two hours in Rome.
The US Open champion failed to win a game in the second set, but she overcame world number 68 Cristian in the third and deciding set.
BBC