Struggling Manchester United returned to type as Pablo Sarabia curled home a brilliant 77th-minute free-kick to secure a fifth straight top-flight win for Wolves for the first time since 1970 and end any lingering fears of relegation.
United's performance could not have been in greater contrast to their thrilling efforts in midweek against Lyon.
They have now lost 15 games this season, more than last term and their worst since 1989-90, when they lost on 16 occasions.
Ruben Amorim's team can now add Wolves to Crystal Palace, Brighton, Bournemouth, Newcastle and Nottingham Forest as teams that have come to Old Trafford since the Portuguese took charge in November and left with maximum points.
United have now taken nine points from their past 10 Premier League games. The only teams they have beaten in that period are Leicester and Ipswich, who are both in the bottom three.
Rasmus Hojlund was inches away from turning home Alejandro Garnacho's low cross at the far post for the hosts but he has now scored once in his last 28 games.
While Amorim has not made United's results better since replacing Erik ten Hag, Vitor Pereira has transformed Wolves.
From being in a relegation dogfight for much of the campaign, they are now safe with five games to spare and are behind today's opponents only on goal difference.
BBC