Barcelona have discovered their fate after the Europa League last 16 draw was held on Monday at UEFA headquarters in Nyon, Switzerland.
The Catalans have been drawn to face Italian side Napoli while Borussia Dortmund must overcome Scottish champions Rangers in order to keep their dreams of savouring continental glory alive.
Serie A entertainers Atalanta take on Greek giants Olympiacos, RB Leipzig face Real Sociedad and Zenit tackle Real Betis.
Elsewhere, Porto will square off against Lazio and Sheriff – fresh from their Champions League adventure – have been paired with Braga.
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Europa League knockout round play-off draw in full
Sevilla vs Dinamo Zagreb
Atalanta vs Olympiacos
RB Leipzig vs Real Sociedad
Barcelona vs Napoli
Zenit vs Real Betis
Borussia Dortmund vs Rangers
Sheriff vs Braga
Porto vs Lazio
Dates for Europa League knockout round play-off fixtures
All ties will be played over two legs, with the first of those taking place on February 17, 2022.
Return dates will be held a week later on February 24.
The victors will join the eight Europa League group winners in the last 16, while the losers exit European competition entirely.
All of those still gunning for glory and hoping to make their way to the final at Ramon Sanchez Pizjuan in Seville on May 18.